ORGANOVO Forum: Community User: Trader_100

Organovo Presents New Preclinical Data on 3D Bioprinted Human Liver Tissues at World Advanced Therapies and Regenerative Medicine Congress SAN DIEGO, May 18, 2017 (GLOBE NEWSWIRE) -- Organovo Holdings, Inc. (NASDAQNVO) (“Organovo”), a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today presented new preclinical data showing extended survival and sustained functionality of its 3D bioprinted human liver tissue when implanted into diseased animal models. This data was presented at the World Advanced Therapies and Regenerative Medicine Congress in London by Benjamin Sheperd, Ph.D., Director of Therapeutics, at Organovo. Organovo previously implanted its 3D bioprinted human liver tissue patches onto the livers of healthy NOD/SCID mice, and is now presenting data from promising early studies in an established model for alpha-one-antitrypsin deficiency. The tissue was composed of human hepatocytes and select non-parenchymal cells. Serum and histopathologic evaluation of the implanted therapeutic tissue showed engraftment, retention and sustained functionality of the bioprinted cellular organization through 60 days post-implantation, a significant increase in duration from the Company’s first preclinical studies, which demonstrated functionality through 28 days. Importantly, these results demonstrate a significant increase in the reported duration of transplanted human hepatocyte synthetic function, and suggest that synthetic function is improved in the animal disease model. Pathologic evaluation of diseased animals receiving transplanted bioprinted liver tissues suggests an improvement in liver health versus non-treated, control animals. “With tens of thousands of patients being treated for inborn errors of metabolism (“IEMs”) in the U.S., and an annual cost per patient that exceeds $250,000 for drug therapy alone, Organovo is advancing novel therapeutic solutions for direct surgical implantation," said Eric David, M.D., J.D., chief strategy officer and executive vice president of preclinical development, Organovo. “Our preclinical data continues to show increased durability of the liver tissue and strong early evidence of successfully impacting the disease state in animal models. The robust presence of key human metabolic enzymes, which we previously disclosed, is also a critical step in demonstrating the capability of this tissue to treat IEMs, a key indication we are targeting. Taken together, these data support continued preclinical development of Organovo’s 3D bioprinted liver tissue for therapeutic use.” Focusing first on pediatric inborn errors of metabolism, Organovo intends to submit an Investigational New Drug (“IND”) application to the U.S. Food and Drug Administration (“FDA”) for its therapeutic liver tissue in calendar-year 2020. In the next 18 months, the Company expects to optimize its final liver tissue design and continue pre-GLP studies, including efficacy, safety and dosing studies in small animal disease models for IEMs. Organovo will also seek orphan designation in the U.S. at the appropriate time and partner with contract research organizations (“CROs”) to define and scope IND enabling studies. 

Welche Aktien gibt es noch , mit 3 D drück die interessanten währen ? Auch im Bio Bereich ?

Gehts über 3 USD kommen die 3.5;)

Wird aber auch zeit...

Hohes Volumen heute in den USA! Sieht wieder gut aus

Aber natürlich! Super News bringen den Kurs jetzt wieder nach oben...

Immer noch bei Wastewater aktiv? ...hab mal geschielt!

Hehe Grüß Dich Nu!

...gucke mal!...alles alte Bekannte hier!

Jeden Tag überlege ich nachzukaufen, bekomm aber den Knopf nicht gedrückt;). Hab mich aber schon auf 2,97 runter geschuftet :)

Anfang juni kommen neue zahlen

Gute Entscheidung. Hohes Volumen heute überm Teich und ein schönes Plus dazu

Habe gestern Abend bei 2,51 noch etwas nachgelegt und lehne mich wieder zurück

Überlege echt noch mal nachzulegen

Warum sollte die nochmal hoch kommen? Es gibt für den abstieg ja nicht einmal eine echte Erklärung. Das sieht mir schwer nach Luft draußen aus...

Kommt schon noch wieder!