BioNTech WKN: A2PSR2 ISIN: US09075V1026 Forum: Aktien Thema: Hauptdiskussion

Dr. Meyer war gegen dich ein Waisenknabe😉 Jetzt freue dich und warte die zwei Jahre bis 2028 ab, bis diese Erfolge monetär wirksam werden 🧘🧘‍♂️

ASCO 2026 ​100 % Krankheitskontrolle (DCR): Tumorwachstum wurde bei allen Patienten gestoppt. Null Sofortversager. ​Massive Ansprechrate (ORR): 72,7 % bis 81,8 % objektive Tumorverkleinerung in der Phase-3-Zieldosis. ​Wettbewerbsvorteil vs. Keytruda: Bewiesene Wirksamkeit auch bei PD-L1-negativen Patienten (dem bisherigen blinden Fleck des Marktes). ​Klinisches De-Risking: Sehr gutes Sicherheitsprofil, nur 4,7 % Therapieabbrüche. ​Marktpotenzial: Klarer Beweis, dass BNT327 den aktuellen "Standard of Care" im Multi-Milliarden-Lungenkrebsmarkt ablösen kann.

Sinkt heute wieder auf <80€. Da mache Ich mir keine Hoffnungen.

Hatte ich schon in das MS Forum gestellt: Phase 2 data from ROSETTA Lung-02, a global randomized phase 2/3 trial of pumitamig (PD-L1 × VEGF-A bsAb) + chemotherapy in 1L NSCLC. Solange Peters Oncology Department, Centre Hospitalier Universitaire Vaudois, Lausanne University, Lausanne, Switzerland Download Media Abstract Background: Pumitamig (BNT327/BMS986545) is an investigational PD-L1 × VEGF-A bsAb designed to restore effector T-cell function by binding PD-L1 and localizing VEGF-A neutralization within the tumor microenvironment. We present the prespecified interim analysis of the Phase 2 dose-optimization part of the global Phase 2/3 ROSETTA Lung-02 trial (NCT06712316) evaluating the recommended Phase 3 dose of pumitamig + chemotherapy in 1L NSCLC. Methods: The Phase 2 part of ROSETTA Lung-02 enrolled pts with treatment-naïve advanced NSCLC, no actionable genomic alterations, regardless of PD-L1 status, ECOG PS ≤1, and ≥1 measurable lesion per RECIST v1.1 into two substudies based on histology (nonsquamous [NSQ] and squamous [SQ]). Pts were randomized 1:1 to 1400 mg (dose level [DL] 1) or 2000 mg (DL2) pumitamig + histology-specific chemotherapy Q3W (NSQ: carboplatin + pemetrexed; SQ: carboplatin + paclitaxel). Primary endpoints were safety, overall response rate (ORR), and best percentage change in tumor size from baseline. Key secondary endpoints include duration of response (DOR) and disease control rate (DCR). Results: The Phase 2 part enrolled 44 pts (NSQ n=23; SQ n=21; data cutoff Nov 21, 2025). Median age was 66 y (range: 41–87), and 27 (61.4%) pts had ECOG PS 1. Among 40 response-evaluable pts, best overall response was CR in 2 pts, PR in 26, and SD in 12, for an ORR of 70.0% (28/40; confirmed ORR was 52.5% [21/40], 5 pending confirmation) and DCR of 100%. DOR data were not mature at the time of data cutoff. Median best change in tumor volume was -38.2% (NSQ -36.6%; SQ -39.7%). In NSQ NSCLC, ORR was 66.7% (14/21) and, by pumitamig dose, it was 72.7% for DL1 (8/11) and 60.0% for DL2 (6/10). In SQ NSCLC, ORR was 73.7% (14/19), 81.8% for DL1 (9/11) and 62.5% for DL2 (5/8). Central PD-L1 levels were available for 35 pts (PD-L1 &lt;1% [n=20], 1–49% [n=9], ≥50% [n=6]), with activity across PD-L1 levels. Circulating tumor DNA dynamics were assessed. Median treatment duration was 4.5 mo (range: 0.1–8.8) with 30 (69.8%) pts still on treatment. In the safety set (N=43), 40 (93.0%) pts had a treatment-related adverse event (TRAE). Grade ≥3 TRAEs were reported in 19 (44.2%) pts and were considered pumitamig-related in 8 (18.6%). Pumitamig-related TRAEs led to treatment discontinuation in 2 (4.7%) pts. Immune-related AEs (irAEs) occurred in 6 (14.0%) pts and grade ≥3 irAEs in 1 (2.3%). Bleeding events were reported in 7 (16.3%) pts, with only 1 event being grade 3. Conclusions: In these first global data for a PD-(L)1 × VEGF-A bsAb in 1L NSCLC regardless of PD-L1 status, pumitamig + chemotherapy showed encouraging efficacy with a manageable safety profile. Efficacy of the lower dose + chemotherapy was particularly encouraging (ORR 72.7% in NSQ, 81.8% in SQ) and is being evaluated vs pembrolizumab + chemotherapy in the ongoing Phase 3 part of the trial. https://www.asco.org/abstracts-presentations/261380

Wo hast du denn die Daten her, in der offiziellen ASCO 2026 App die ich auch schon lange besitze, ist nichts zu finden und im www auch. Ich. Hast du einen Link? Wenn das so wäre dann hätten wir seit langem mal etwas positives vorzubringen.

ASCO 2026 ​100 % Krankheitskontrolle (DCR): Tumorwachstum wurde bei allen Patienten gestoppt. Null Sofortversager. ​Massive Ansprechrate (ORR): 72,7 % bis 81,8 % objektive Tumorverkleinerung in der Phase-3-Zieldosis. ​Wettbewerbsvorteil vs. Keytruda: Bewiesene Wirksamkeit auch bei PD-L1-negativen Patienten (dem bisherigen blinden Fleck des Marktes). ​Klinisches De-Risking: Sehr gutes Sicherheitsprofil, nur 4,7 % Therapieabbrüche. ​Marktpotenzial: Klarer Beweis, dass BNT327 den aktuellen "Standard of Care" im Multi-Milliarden-Lungenkrebsmarkt ablösen kann.

Es geht nicht um Ebola es geht drum, dass bereits der kleine Abstract zeigt was Ende Mai auf der Asco abgeht... Die Zeit der Rakete ist gekommen. Nun fliegen wir zu den 500.